Physical effects: A number of varied physical effects are associated with taking Molly, including blurred vision, nausea, vomiting, muscle cramping, appetite loss, hyperactivity, and teeth grinding that can lead to problems with severe wear and tear on the teeth. Increased body temperature: One of the immediate effects of taking MDMA is its effects on the sympathetic nervous system, which acts to speed up various bodily functions. People who use the drug become at risk for overheating (hyperthermia) and dehydration due to excessive sweating, especially when they are using the drug in crowded environments. This can also lead to the development of seizures and other potentially serious issues.

Mood swings: MDMA use results in massive neurotransmitter release in the brain that is later offset by a depletion of neurotransmitters when the individual has stop using the drug. This results in a cycle of mood swings that include euphoria and sociability while under the influence of MDMA and severe depression, hopelessness, and apathy after one has stopped taking the drug. Other psychological issues that occur with long-term use of the drug include issues with anxiety, poor judgment, impulsive behavior, reduced sex drive, and increased aggressive behaviors.

The physical dependence on MDMA Crystal: Chronic use of MDMA may be associates with the development of physical dependence (the development of both tolerance and withdrawal syndromes); however, the research is mix regarding this. There is no formal  recognize withdrawal syndrome

associated with the chronic use of MDMA, although it is generally recognize that tolerance to MDMA does develop. In the sources where withdrawal from MDMA is describe, the withdrawal syndrome consists primarily of psychological symptoms, such as fatigue, depression, difficulty concentrating, issues with sleep, and other similar symptoms.

Substance use disorders: Chronic use of Molly can result in the development of a substance use disorder.

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The American Psychiatric Association (APA) and other professional organizations still use the terms addiction and abuse in their discussions of addictive behaviors; however, in terms of the formal diagnosis of addictive behaviors to drugs, the term substance use disorder has replaced these terms. This is because research studies and the experiences of clinicians agree that the terms substance abuse and addiction do not describe mutually exclusive conditions. Instead, addictive behaviors occur on a continuum from use to abuse to the development of a formal psychological disorder. The development of a substance use disorder as a result of MDMA

abuse would be label a hallucinogen use disorder under the current diagnostic scheme. According to APA, the signs of a hallucinogen use disorder includes Ecstasy drug.